A deep exploration of the energy conservation and emission reduction potential of the industrial symbiosis system, along with promoting cross-industry and cross-regional synergistic consumption and utilization of multi-source solid waste, is an important tool for addressing the compound environmental pollution problems of heavy industries and population-dense areas, such as the Beijing-Tianjin-Hebei Region. At present, the scientific design of a systematic industrial symbiosis solution that matches the spatial characteristics of regional waste generation and discharge faces three major challenges: Unclear data on multi-source solid waste generation and discharge, unclear symbiosis pathways, and difficulties in assessing the energy conservation and emission reduction potential of the industrial symbiosis solution. The purpose of this study is to use the Beijing-Tianjin-Hebei Region as an example to construct a spatial map of multi-source solid waste generation and discharge. Based on this, a complex system optimization method is introduced to develop a multi-source solid waste cross-industry and cross-region symbiotic utilization plan. Finally, the environmental and economic performance of the plan is quantitatively evaluated using a bottom-up approach, with key symbiotic regions, enterprises, and technologies identified. The methodology of this study is expected to provide a replicable model for the spatial and refined management of industrial symbiosis in other regions and even across the country.