The paper has put forward our own opinion about how to realize to signify、comprehend and solve complicated problem on metasynthesis research domain. And based on the complicated decision ma king problem, the paper has also built up the three levels theory framework of metasynthesis, which is more suitable to the human thinking habit. The theory framework consists of the predigestion process level of complicated problem, the quantitative analysis level, and the qualitative and quantitative metasynthesis solving leve1．At the same time．we have discussed the main research contents of the three levels in the paper．In addition，the paper gave a beneficial discussion about how to realize pure man-machine integration in the process of solving complicated problem using metasynthesis