In terms of HeXie Management Theory and the research findings of brain science, this paper compares and analyzes the principle of brain function and HeXie Coupling mechanism. The basic model of HeXie Management on complexity problem solving is presented, and the ＂mechanism-order＂ model of HeXie Coupling on the level of rule system is discussed. The model points out that HeXie Coupling is a dynamic and evolving process, during which He Principle and Xie Principle under HeXie Theme adjust to each other at different levels of the organizational network. And it is HeXie Coupling that helps inducement evolution and rational design to realize the coherence of organization as a whole