This paper investigates the effect of CEO openness on organizational strategy persistence．Results from the data of listed companies in China from 2003 to 2009 show that CEO openness has significantly negative effect on strategy persistence．As the level of CEO openness gets higher，the organization tend to adjust the strategic resource allocation according to environmental changing．Moreover，the result indicates that this relationship is moderated by CEO shareholding negatively，and the negative effect of CEO openness on strategic persistence is much stronger when open a CEO has more managerial discretion．The result also finds that the effect of CEO openness on strategy persistence is heterogeneous in different organization-institutional situations，because of the influence of special institution characteristics and certain social functions; the negative effect of CEO openness is much less significant for State-Owned Enterprises relative to family firms．This paper further extends the knowledge about the effect of strategy persistence on firm value: strategy persistence has an inverted-U-shaped rather than a linear relationship with firm performance．