This article focused on the impact of organizational inertia in the evolution process of cluster network．Firstly，an analysis framework of organizational inertia was proposed based on structural and cognitive dimensions． Secondly，the network behaviors of individual firms were defined in the consideration of organizational inertia． Then，a comparative analysis was conducted based on multi-agent simulation in the existence of different inertia． The main conclusions of this article are: (1) Organizational inertia comes from two aspects:one is structural inertia，derived from structural elements such as institutions，standards，routines，etc． ; the other is cognitive inertia，rooted in the cognitive system，environment perception mode，previous knowledge and experience; (2) Organizational inertia enhances the sustainable development capability of cluster networks． The structural inertia is much more significant than the cognitive inertia． (3) Organizational inertia reduced the small world phenomenon and made the factions’differentiation even worse． At the same time，the increasing efficiency of interior fractions enhanced the overall efficiency of the cluster network．