The paper studies the different impacts of the design of both the efficiency-centered business model and the novelty-centered business model based on CAS (Complexity Adaptive System) theory. After rethinking the dependent variable——organizational adaptation——affecting the design of the business model and using the “orderly” state and “edge of chaos” state of complex adaptive systems to analyze the design of the two type of models, the empirical testing finds that the design of the efficiency-centered business model has a positive relationship with the simple adaptation, and the design of the novelty-centered business model has a positive relationship with the complex adaptation. Furthermore, referring to the concept of “the law of requisite variety” and “systematic complexity matched environmental complexity”, the paper puts forward the idea that the basis of enterprise adaptive evolution is whether the design of the business model matches with internal organizational complexity and external environmental uncertainty. When the organizational structure, strategy and objectives are simple and the environment is stable, enterprises should design the efficiency-centered business model; when the organizational structure is complex, the business strategy and objectives are diversified, and the environment is complex and dynamic, enterprises should design the novelty-centered business model.