Neuro information system is the application of cognitive neuroscience theories，methods，and tools in the field of information systems． It studies and solves the problems in information systems from a new methodological perspective． Neuro information system studies focus on three fields: System design and optimization， information service and decision-making，and social networks and interactions． The main research paradigms can be divided into three categories: The paradigm of information system experiment，the application of psychology and decision science in information systems，and the combination of multiple tasks and multiple methods． The methods of neuro information system can effectively make up for the disadvantages of traditional information system studies by controlling response bias，realizing the precise measurement of user’s psychological process，exploring the neural mechanism of user decision-making，and developing the method and theory of information system research． By exploring the problems which traditional information system have not solved or where there are still controversies，neuro information system study can enrich the existing theory，reveal the mechanism of user information decision-making，open the“black box”，and promote the information system to be“more objective”and“more in-depth”． The research theories and methods in neuro information system put forward a new historical mission for the scholars，and create new historical opportunities．