Epidemic diffusion has made great damages to human life and development. Controlling epidemic diffusion is an important issue for all social societies. During the fight against public health emergencies, government have made arduous efforts to control virus diffusion to ensure people’s safety, such as strengthening media propaganda, controlling population travels, and so on. In this paper, sets of heterogeneous data about disease diffusion are collected and combined. After a careful analysis of the data, the disease diffusion process is divided into 3 stages. Media propaganda and population travels are quantified with parameters, and the classical states of disease transition model are extended from 3 to 5. A two-associative-strategy disease diffusion control model, based media propaganda and population travels, is presented. Numerical simulations and empirical data fittings demonstrate that the two-strategy control model is efficient and feasible in deceasing epidemic diffusion.